1-(1-Methyl-4-piperidinyl)piperazine → HCID 135474519, compound

HRID 644345Notes

Reaction equation

HRID 644345 reaction equation
[O:1]=[C:2]1[N:6]([CH:7]2[CH2:12][CH2:11][N:10]([C:13]([NH:15][C@H:16]([CH2:20][C:21]3[CH:30]=[CH:29][C:28]4[CH2:27][CH2:26][CH2:25][CH2:24][C:23]=4[CH:22]=3)[C:17](O)=[O:18])=[O:14])[CH2:9][CH2:8]2)[N:5]=[C:4]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[NH:3]1.[CH3:37][N:38]1[CH2:43][CH2:42][CH:41]([N:44]2[CH2:49][CH2:48][NH:47][CH2:46][CH2:45]2)[CH2:40][CH2:39]1>>[CH3:37][N:38]1[CH2:39][CH2:40][CH:41]([N:44]2[CH2:49][CH2:48][N:47]([C:17](=[O:18])[C@H:16]([NH:15][C:13]([N:10]3[CH2:11][CH2:12][CH:7]([N:6]4[C:2](=[O:1])[NH:3][C:4]([C:31]5[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=5)=[N:5]4)[CH2:8][CH2:9]3)=[O:14])[CH2:20][C:21]3[CH:30]=[CH:29][C:28]4[CH2:27][CH2:26][CH2:25][CH2:24][C:23]=4[CH:22]=3)[CH2:46][CH2:45]2)[CH2:42][CH2:43]1

Participants

3

Reactant 2

HCID 5663241-(1-Methyl-4-piperidinyl)piperazineHCID 136375897HCID 136375897, compound

Product 1

HCID 135474519HCID 135474519, compound

Procedure

Prepared analogously to Example 54c) from 300 mg (0.61 mmol) (R)-2-{[4-(5-oxo-3-phenyl-4,5-dihydro-[1,2,4]triazol-1-yl)-piperidine-1-carbonyl]-amino}-3-(5,6,7,8-tetrahydro-naphthalen-2-yl)-propionic acid and 120 mg (0.66 mmol) 1-(1-methyl-piperidin-4-yl)-piperazine.

Sources & evidence

ORD record
ord-1f2694e612b84f37abd0a687f27c5525
Source dataset
uspto-grants-2010_04
Patent number
US07700589B2

Reaction notes

Loading…