Tetrahydrofuran → HCID 68579296, compound

Participants

Reaction Steps

87 mg (2.0 mmol) sodium hydride (55% in mineral oil) were added to an ice-cooled mixture of 600 mg (1.9 mmol) benzyl (R)-2-amino-3-(3,4-diethyl-phenyl)-propionate and 40 mL THF, stirred for 30 min at RT, cooled in the ice bath and 660 mg (2.1 mmol) 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carbonylchloride in 20 mL THF were added dropwise within 10 min. The reaction mixture was stirred for a further 30 min while cooling with ice and for 1 h at RT and then evaporated down under reduced pressure. The residue was taken up in EtOAc and purified by chromatography on silica gel.

Provenance & Evidence