HCID 68579296, compound → HCID 68578903, compound

HRID 644350Notes

Reaction equation

HRID 644350 reaction equation
[O:1]=[C:2]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@@H:18]([C:30]([O:32]CC3C=CC=CC=3)=[O:31])[CH2:19][C:20]3[CH:25]=[CH:24][C:23]([CH2:26][CH3:27])=[C:22]([CH2:28][CH3:29])[CH:21]=3)=[O:16])[CH2:11][CH2:10]2)[CH2:7][CH2:6][C:5]2[CH:40]=[CH:41][CH:42]=[CH:43][C:4]=2[NH:3]1.[H][H]>[Pd].CO>[O:1]=[C:2]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@@H:18]([C:30]([OH:32])=[O:31])[CH2:19][C:20]3[CH:25]=[CH:24][C:23]([CH2:26][CH3:27])=[C:22]([CH2:28][CH3:29])[CH:21]=3)=[O:16])[CH2:11][CH2:10]2)[CH2:7][CH2:6][C:5]2[CH:40]=[CH:41][CH:42]=[CH:43][C:4]=2[NH:3]1

Participants

5

Reactant 2

HCID 68579296HCID 68579296, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 68578903HCID 68578903, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 350 mg (0.60 mmol) (R)-1-benzyloxycarbonyl-2-(3,4-diethyl-phenyl)-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate and 30 mL MeOH was hydrogenated in the presence of 50 mg Pd/C (5%) at RT and 3 bar hydrogen pressure until the calculated volume of hydrogen had been taken up. The catalyst was filtered off, the solvent was eliminated under reduced pressure.

Workup

  1. filtrationThe catalyst was filtered off

Sources & evidence

ORD record
ord-d7ae33f9b389405fbc004e2f8ba3a4bd
Source dataset
uspto-grants-2010_04
Patent number
US07700589B2

Reaction notes

Loading…