HCID 57848489, compound → HCID 10009167, compound

HRID 644358Notes

Reaction equation

HRID 644358 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([CH2:11][C@@H:12]([NH:16][C:17]([N:19]2[CH2:24][CH2:23][CH:22]([N:25]3[CH2:31][CH2:30][C:29]4[CH:32]=[CH:33][CH:34]=[CH:35][C:28]=4[NH:27][C:26]3=[O:36])[CH2:21][CH2:20]2)=[O:18])[C:13](O)=[O:14])[CH:6]=[CH:7][C:8]=1[CH2:9][CH3:10])[CH3:2].[NH:37]1[CH2:40][CH:39]([N:41]2[CH2:47][CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]2)[CH2:38]1>>[N:41]1([CH:39]2[CH2:38][N:37]([C:13](=[O:14])[C@H:12]([NH:16][C:17]([N:19]3[CH2:24][CH2:23][CH:22]([N:25]4[CH2:31][CH2:30][C:29]5[CH:32]=[CH:33][CH:34]=[CH:35][C:28]=5[NH:27][C:26]4=[O:36])[CH2:21][CH2:20]3)=[O:18])[CH2:11][C:5]3[CH:6]=[CH:7][C:8]([CH2:9][CH3:10])=[C:3]([CH2:1][CH3:2])[CH:4]=3)[CH2:40]2)[CH2:47][CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]1

Participants

3

Reactant 2

HCID 57848489HCID 57848489, compoundHCID 68579001(R)-3-(3,4-diethyl-phenyl)-2-{[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carbonyl]-amino}-propionic acid

Product 1

HCID 10009167HCID 10009167, compound

Procedure

Prepared analogously to Example 34 from (R)-3-(3,4-diethyl-phenyl)-2-{[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carbonyl]-amino}-propionic acid and 1-azetidin-3-yl-perhydro-azepine.

Sources & evidence

ORD record
ord-fa7cda7b4f3f4484851a253d987bfab2
Source dataset
uspto-grants-2010_04
Patent number
US07700589B2

Reaction notes

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