3-(Piperidin-4-yl)-4,5-dihydro-1H-benzo[d][1,3]diazepin-2(3H)-one → HCID 178436270, compound

HRID 644363Notes

Reaction equation

HRID 644363 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:13][CH2:12][C:11]3[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=3[NH:9][C:8]2=[O:18])[CH2:3][CH2:2]1.[NH2:19][C@H:20]([CH2:36][C:37]1[CH:42]=[CH:41][C:40]([CH2:43][CH3:44])=[C:39]([CH2:45][CH3:46])[CH:38]=1)[C:21]([N:23]1[CH2:28][CH2:27][CH:26]([N:29]2[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]2)[CH2:25][CH2:24]1)=[O:22]>>[CH2:45]([C:39]1[CH:38]=[C:37]([CH:42]=[CH:41][C:40]=1[CH2:43][CH3:44])[CH2:36][C@@H:20]([NH:19]/[C:4](=[N:7]/[C:8]#[N:9])/[N:1]1[CH2:2][CH2:3][CH:4]([N:7]2[CH2:13][CH2:12][C:11]3[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=3[NH:9][C:8]2=[O:18])[CH2:5][CH2:6]1)[C:21]([N:23]1[CH2:28][CH2:27][CH:26]([N:29]2[CH2:30][CH2:31][N:32]([CH3:35])[CH2:33][CH2:34]2)[CH2:25][CH2:24]1)=[O:22])[CH3:46]

Participants

3

Reactant 2

HCID 113795873-(Piperidin-4-yl)-4,5-dihydro-1H-benzo[d][1,3]diazepin-2(3H)-oneHCID 68578923HCID 68578923, compound

Product 1

HCID 178436270HCID 178436270, compound

Procedure

Prepared analogously to Example 73 from 3-piperidin-4-yl-1,3,4,5-tetrahydrobenzo[d][1,3]diazepin-2-one and (R)-2-amino-3-(3,4-diethyl-phenyl)-1-[4-(4-methylpiperazin-1-yl)-piperidin-1-yl]-propan-1-one

Sources & evidence

ORD record
ord-ddc5b70dd6ac44c294e4d4938b4c5314
Source dataset
uspto-grants-2010_04
Patent number
US07700589B2

Reaction notes

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