3-(Piperidin-4-yl)-4,5-dihydro-1H-benzo[d][1,3]diazepin-2(3H)-one → HCID 178436269, compound

HRID 644364Notes

Reaction equation

HRID 644364 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:13][CH2:12][C:11]3[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=3[NH:9][C:8]2=[O:18])[CH2:3][CH2:2]1.[NH2:19][C@H:20]([CH2:35][C:36]1[CH:41]=[CH:40][C:39]([CH2:42][CH3:43])=[C:38]([CH2:44][CH3:45])[CH:37]=1)[C:21]([N:23]1[CH2:28][CH2:27][CH:26]([N:29]2[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]2)[CH2:25][CH2:24]1)=[O:22]>>[N:29]1([CH:26]2[CH2:27][CH2:28][N:23]([C:21](=[O:22])[C@H:20]([NH:19]/[C:4](=[N:7]/[C:8]#[N:9])/[N:1]3[CH2:2][CH2:3][CH:4]([N:7]4[CH2:13][CH2:12][C:11]5[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=5[NH:9][C:8]4=[O:18])[CH2:5][CH2:6]3)[CH2:35][C:36]3[CH:41]=[CH:40][C:39]([CH2:42][CH3:43])=[C:38]([CH2:44][CH3:45])[CH:37]=3)[CH2:24][CH2:25]2)[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 113795873-(Piperidin-4-yl)-4,5-dihydro-1H-benzo[d][1,3]diazepin-2(3H)-oneHCID 68579170HCID 68579170, compound

Product 1

HCID 178436269HCID 178436269, compound

Procedure

Prepared analogously to Example 73 from 3-piperidin-4-yl-1,3,4,5-tetrahydrobenzo[d][1,3]diazepin-2-one and (R)-2-amino-1-[1,4′]bipiperidinyl-1′-yl-3-(3,4-diethylphenyl)-propan-1-one

Sources & evidence

ORD record
ord-af83db7e8fc04159b6c6c1c2cefb7957
Source dataset
uspto-grants-2010_04
Patent number
US07700589B2

Reaction notes

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