HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-(3,4-Dimethyl-phenyl)-3,3-bis-ethoxycarbonyl-butanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 4-(3,4-dimethyl-phenyl)-3,3-bis-ethoxycarbonyl-butanoate | HCID 68581313 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(3,4-Dimethyl-phenyl)-3,3-bis-ethoxycarbonyl-butanoic acid | HCID 68578993 | — |
Reaction Steps
A mixture of 11.6 g (29.5 mmol) tert-butyl 4-(3,4-dimethyl-phenyl)-3,3-bis-ethoxycarbonyl-butanoate and 100 mL DCM was combined with 20 mL TFA, the reaction mixture was stirred for 3 h at RT and evaporated down under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700589B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-c4135609634341fd88e5448e362da702 |
| Source note | uspto-grants-2010_04 |