1-Methyl-4-(piperidin-4-yl)piperazine → 2-(3,4-dimethyl-benzyl)-1-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butan-1,4-dione

Participants

Role	Name	HCID	Charge
Reactant	1-Methyl-4-(piperidin-4-yl)piperazine	HCID 795707	—
Reactant	2-(3,4-dimethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butanoic acid	HCID 68581057	—
Product	2-(3,4-dimethyl-benzyl)-1-[4-(4-methyl-piperazin-1-yl)-piperidin-1-yl]-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butan-1,4-dione	HCID 59260993	—

Reaction Steps

Prepared analogously to Example 76e) from 2-(3,4-dimethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butanoic acid and 1-methyl-4-piperidin-4-yl-piperazine

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07700589B2
Source dataset	uspto-grants-2010_04
ORD ID	ord-72937cd592094743b17328404c4fbe14
Source note	uspto-grants-2010_04