1-(Piperidin-4-yl)-4-(propan-2-yl)piperazine → 2-(3,4-dimethyl-benzyl)-1-[4-(4-isopropyl-piperazin-1-yl)-piperidin-1-yl]-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butan-1,4-dione

HRID 644373Notes

Reaction equation

HRID 644373 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][C:32]=1[CH3:33])[CH2:5][CH:6]([CH2:10][C:11](=[O:29])[N:12]1[CH2:17][CH2:16][CH:15]([N:18]2[CH2:27][C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[NH:20][C:19]2=[O:28])[CH2:14][CH2:13]1)[C:7](O)=[O:8].[CH:34]([N:37]1[CH2:42][CH2:41][N:40]([CH:43]2[CH2:48][CH2:47][NH:46][CH2:45][CH2:44]2)[CH2:39][CH2:38]1)([CH3:36])[CH3:35]>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][C:32]=1[CH3:33])[CH2:5][CH:6]([CH2:10][C:11]([N:12]1[CH2:13][CH2:14][CH:15]([N:18]2[CH2:27][C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[NH:20][C:19]2=[O:28])[CH2:16][CH2:17]1)=[O:29])[C:7]([N:46]1[CH2:45][CH2:44][CH:43]([N:40]2[CH2:39][CH2:38][N:37]([CH:34]([CH3:36])[CH3:35])[CH2:42][CH2:41]2)[CH2:48][CH2:47]1)=[O:8]

Participants

3

Reactant 2

HCID 282830301-(Piperidin-4-yl)-4-(propan-2-yl)piperazineHCID 685810572-(3,4-dimethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butanoic acid

Product 1

HCID 592609722-(3,4-dimethyl-benzyl)-1-[4-(4-isopropyl-piperazin-1-yl)-piperidin-1-yl]-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butan-1,4-dione

Procedure

Prepared analogously to Example 76e) from 2-(3,4-dimethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butanoic acid and 1-isopropyl-4-piperidin-4-yl-piperazine

Sources & evidence

ORD record
ord-e9630011d1084ff4875d0922a4635515
Source dataset
uspto-grants-2010_04
Patent number
US07700589B2

Reaction notes

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