1-(Methylsulfonyl)-4-(4-piperidinyl)piperazine → 2-(3,4-dimethyl-benzyl)-1-[4-(4-methanesulphonyl-piperazin-1-yl)-piperidin-1-yl]-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butan-1,4-dione

HRID 644374Notes

Reaction equation

HRID 644374 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][C:32]=1[CH3:33])[CH2:5][CH:6]([CH2:10][C:11](=[O:29])[N:12]1[CH2:17][CH2:16][CH:15]([N:18]2[CH2:27][C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[NH:20][C:19]2=[O:28])[CH2:14][CH2:13]1)[C:7](O)=[O:8].[CH3:34][S:35]([N:38]1[CH2:43][CH2:42][N:41]([CH:44]2[CH2:49][CH2:48][NH:47][CH2:46][CH2:45]2)[CH2:40][CH2:39]1)(=[O:37])=[O:36]>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][C:32]=1[CH3:33])[CH2:5][CH:6]([CH2:10][C:11]([N:12]1[CH2:17][CH2:16][CH:15]([N:18]2[CH2:27][C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[NH:20][C:19]2=[O:28])[CH2:14][CH2:13]1)=[O:29])[C:7]([N:47]1[CH2:48][CH2:49][CH:44]([N:41]2[CH2:40][CH2:39][N:38]([S:35]([CH3:34])(=[O:36])=[O:37])[CH2:43][CH2:42]2)[CH2:45][CH2:46]1)=[O:8]

Participants

3

Reactant 2

HCID 282710281-(Methylsulfonyl)-4-(4-piperidinyl)piperazineHCID 685810572-(3,4-dimethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butanoic acid

Product 1

HCID 592609832-(3,4-dimethyl-benzyl)-1-[4-(4-methanesulphonyl-piperazin-1-yl)-piperidin-1-yl]-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butan-1,4-dione

Procedure

Prepared analogously to Example 76e) from 2-(3,4-dimethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butanoic acid and 1-methanesulphonyl-4-piperidin-4-yl-piperazine.

Sources & evidence

ORD record
ord-51806bbba83f4ad88b1d493a263cc4db
Source dataset
uspto-grants-2010_04
Patent number
US07700589B2

Reaction notes

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