1-Methyl-4,4'-bipiperidine → 4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidine-1-carboxylic acid [1-(3,4-dimethyl-benzyl)-2-(1'-methyl-[4,4']bipiperidinyl-1-yl)-2-oxo-ethyl]-amide

HRID 644379Notes

Reaction equation

HRID 644379 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:9][CH:10]([NH:14][C:15]([N:17]2[CH2:22][CH2:21][CH:20]([N:23]3[CH2:32][C:31]4[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=4)[NH:25][C:24]3=[O:33])[CH2:19][CH2:18]2)=[O:16])[C:11]([OH:13])=O)[CH:5]=[CH:6][C:7]=1[CH3:8].[CH3:34][N:35]1[CH2:40][CH2:39][CH:38]([CH:41]2[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]2)[CH2:37][CH2:36]1>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[CH3:8])[CH2:9][CH:10]([NH:14][C:15]([N:17]1[CH2:18][CH2:19][CH:20]([N:23]2[CH2:32][C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[NH:25][C:24]2=[O:33])[CH2:21][CH2:22]1)=[O:16])[C:11]([N:44]1[CH2:45][CH2:46][CH:41]([CH:38]2[CH2:37][CH2:36][N:35]([CH3:34])[CH2:40][CH2:39]2)[CH2:42][CH2:43]1)=[O:13]

Participants

3

Reactant 2

HCID 71830411-Methyl-4,4'-bipiperidineHCID 68580202HCID 68580202, compound

Product 1

HCID 592609714-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidine-1-carboxylic acid [1-(3,4-dimethyl-benzyl)-2-(1'-methyl-[4,4']bipiperidinyl-1-yl)-2-oxo-ethyl]-amide

Procedure

Prepared analogously to Example 83d) from 3-(3,4-dimethyl-phenyl)-2-{[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidine-1-carbonyl]-amino}-propionic acid and 1-methyl-[4,4′]bipiperidinyl.

Sources & evidence

ORD record
ord-e65d0f5bedaa412db8808b9750a587e0
Source dataset
uspto-grants-2010_04
Patent number
US07700589B2

Reaction notes

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