4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-2-(5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-butanoic acid → methyl {1'-[4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-2-(5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-butyryl]-[4,4']bipiperidinyl-1-yl}-acetate

HRID 644384Notes

Reaction equation

[O:1]=[C:2]([N:19]1[CH2:24][CH2:23][CH:22]([N:25]2[CH2:34][C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[NH:27][C:26]2=[O:35])[CH2:21][CH2:20]1)[CH2:3][CH:4]([CH2:8][C:9]1[CH:18]=[CH:17][C:16]2[CH2:15][CH2:14][CH2:13][CH2:12][C:11]=2[CH:10]=1)[C:5](O)=[O:6].[N:36]1([CH2:48][C:49]([O:51][CH3:52])=[O:50])[CH2:41][CH2:40][CH:39]([CH:42]2[CH2:47][CH2:46][NH:45][CH2:44][CH2:43]2)[CH2:38][CH2:37]1>>[O:1]=[C:2]([N:19]1[CH2:20][CH2:21][CH:22]([N:25]2[CH2:34][C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[NH:27][C:26]2=[O:35])[CH2:23][CH2:24]1)[CH2:3][CH:4]([CH2:8][C:9]1[CH:18]=[CH:17][C:16]2[CH2:15][CH2:14][CH2:13][CH2:12][C:11]=2[CH:10]=1)[C:5]([N:45]1[CH2:46][CH2:47][CH:42]([CH:39]2[CH2:40][CH2:41][N:36]([CH2:48][C:49]([O:51][CH3:52])=[O:50])[CH2:37][CH2:38]2)[CH2:43][CH2:44]1)=[O:6]

Participants

Reactant 2

HCID 685791034-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-2-(5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-butanoic acid

HCID 70056900Methyl[4,4']bipiperidinyl-1-yl-acetate

Product 1

HCID 59260973methyl {1'-[4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-2-(5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-butyryl]-[4,4']bipiperidinyl-1-yl}-acetate

Procedure

Prepared analogously to Example 76e) from 4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-2-(5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-butanoic acid and methyl [4,4′]bipiperidinyl-1-yl-acetate.

Sources & evidence

ORD record: ord-740fa9bdbc634a288c5f6de0099a6fb1
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07700589B2

Reaction notes

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