Benzenamine, 3,5-bis(trifluoromethyl)- → N-[3,5-Bis(trifluoromethyl)phenyl]-5-[(1,1-dimethyl)ethyl]-2-hydroxybenzamide

HRID 644404Notes

Reaction equation

HRID 644404 reaction equation
[CH3:1][C:2]([C:5]1[CH:13]=[C:9]([C:10]([OH:12])=O)[C:8]([OH:14])=[CH:7][CH:6]=1)([CH3:4])[CH3:3].[F:15][C:16]([F:29])([F:28])[C:17]1[CH:18]=[C:19]([CH:21]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:23]=1)[NH2:20]>>[F:15][C:16]([F:28])([F:29])[C:17]1[CH:18]=[C:19]([NH:20][C:10](=[O:12])[C:9]2[CH:13]=[C:5]([C:2]([CH3:1])([CH3:3])[CH3:4])[CH:6]=[CH:7][C:8]=2[OH:14])[CH:21]=[C:22]([C:24]([F:25])([F:27])[F:26])[CH:23]=1

Participants

3

Reactant 2

HCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-HCID 852815-(1,1-Dimethylethyl)salicylic acid

Product 1

HCID 10250695N-[3,5-Bis(trifluoromethyl)phenyl]-5-[(1,1-dimethyl)ethyl]-2-hydroxybenzamideYield 53.8%

Procedure

Using 5-[(1,1-dimethyl)ethyl]salicylic acid and 3,5-bis(trifluoromethyl)aniline as the raw materials, the same operation as the Example 16 gave the title compound.

Sources & evidence

ORD record
ord-4a960ed8ca024b0096abd3cb23b4c7ac
Source dataset
uspto-grants-2010_04
Patent number
US07700655B2

Reaction notes

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