HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Ethyl 3-hydroxy-2-(hydroxymethyl)-2-(pyridin-3-yl)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | 2-Ethylpyridin-3-yl acetate | HCID 67121346 | — |
| Product | Ethyl 3-hydroxy-2-(hydroxymethyl)-2-(pyridin-3-yl)propanoate | HCID 86713459 | — |
Reaction Steps
To a solution of 2 g of ethylpyridin-3-yl acetate in 40 ml of DMF were added 1.09 g of paraformaldehyde and 165 mg of sodium ethoxide, followed by stirring for 19 hours. Acetic acid was added thereto under ice-cooling and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain 1.29 g of ethyl 3-hydroxy-2-(hydroxymethyl)-2-(pyridin-3-yl)propanoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09447090B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-c423c256e75e469896da3a8ae76155aa |
| Source note | uspto-grants-2016_09 |