反应详情

A mixture of N-[3,5-bis(trifluoromethyl)phenyl]-2-methoxy-5-sulfamoyl-benzamide (compound of Example 87(2); 442 mg, 1 mmol), 2,5-dimethoxytetrahydrofuran (159 mg, 1.2 mmol) and acetic acid (5 mL) was refluxed for 2 hours. After cooling, the reaction mixture was poured into water and extracted with ethyl acetate. After the organic layer was washed with water, saturated aqueous sodium hydrogen carbonate and brine, dried over anhydrous magnesium sulfate, the residue obtained by evaporation of the solvent under reduced pressure was purified by chromatography on silica gel (n-hexane:ethyl acetate=3:2) to give the title compound (436.5 mg, 88.6%) as a white solid.

1. temperaturewas refluxed for 2 hours
2. temperatureAfter cooling
3. extractionextracted with ethyl acetate
4. washAfter the organic layer was washed with water, saturated aqueous sodium hydrogen carbonate and brine
5. dry with materialdried over anhydrous magnesium sulfate
6. customthe residue obtained by evaporation of the solvent under reduced pressure
7. customwas purified by chromatography on silica gel (n-hexane:ethyl acetate=3:2)