Ethyl 2-amino-4-phenyl-1,3-thiazole-5-carboxylate → HCID 9981196, compound

HRID 644446Notes

Reaction equation

HRID 644446 reaction equation
[OH:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]2[S:12][CH:13]=[CH:14][CH:15]=2)=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH2:16]([O:18][C:19]([C:21]1[S:25][C:24]([NH2:26])=[N:23][C:22]=1[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)=[O:20])[CH3:17]>>[CH2:16]([O:18][C:19]([C:21]1[S:25][C:24]([NH:26][C:4](=[O:6])[C:3]2[CH:7]=[C:8]([C:11]3[S:12][CH:13]=[CH:14][CH:15]=3)[CH:9]=[CH:10][C:2]=2[OH:1])=[N:23][C:22]=1[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)=[O:20])[CH3:17]

Participants

3

Reactant 2

HCID 73239Ethyl 2-amino-4-phenyl-1,3-thiazole-5-carboxylateHCID 41284632-Hydroxy-5-(2-thienyl)benzoic acid

Product 1

HCID 9981196HCID 9981196, compoundYield 58.2%

Procedure

Using 2-hydroxy-5-(2-thienyl)benzoic acid and 2-amino-4-phenylthiazole-5-carboxylic acid ethyl ester as the raw materials, the same operation as the Example 195(3) gave the title compound.

Sources & evidence

ORD record
ord-a76599d1d5bf428e85864de8e2d6789a
Source dataset
uspto-grants-2010_04
Patent number
US07700655B2

Reaction notes

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