Benzenamine, 3,5-bis(trifluoromethyl)- → (S)-2-Amino-4-methyl-N-[3,5-bis(trifluoromethyl)phenyl]pentanamide

HRID 644456Notes

Reaction equation

HRID 644456 reaction equation
C(OC([NH:8][C@H:9]([C:14](O)=[O:15])[CH2:10][CH:11]([CH3:13])[CH3:12])=O)(C)(C)C.[F:17][C:18]([F:31])([F:30])[C:19]1[CH:20]=[C:21]([CH:23]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:25]=1)[NH2:22]>>[NH2:8][C@@H:9]([CH2:10][CH:11]([CH3:13])[CH3:12])[C:14]([NH:22][C:21]1[CH:20]=[C:19]([C:18]([F:30])([F:31])[F:17])[CH:25]=[C:24]([C:26]([F:27])([F:28])[F:29])[CH:23]=1)=[O:15]

Participants

3

Reactant 2

HCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-HCID 83170L-Leucine, N-((1,1-dimethylethoxy)carbonyl)-

Product 1

HCID 57459265(S)-2-Amino-4-methyl-N-[3,5-bis(trifluoromethyl)phenyl]pentanamideYield 25.2%

Procedure

Using N-(tert-butoxycarbonyl)-L-leucine and 3,5-bis(trifluoromethyl)aniline as the raw materials, the same operation as the Example 302(1) gave the title compound.

Sources & evidence

ORD record
ord-f9dd761d0e5f438fb9f8438fb907e12d
Source dataset
uspto-grants-2010_04
Patent number
US07700655B2

Reaction notes

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