5-Chlorosalicylic Acid → 5-Chloro-N-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]-2-hydroxybenzamide

HRID 644477Notes

Reaction equation

HRID 644477 reaction equation
[Cl:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[NH2:12][C:13]1[S:14][CH:15]=[C:16]([C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=2)[N:17]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:12][C:13]1[S:14][CH:15]=[C:16]([C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=2)[N:17]=1)=[O:9]

Participants

3

Reactant 2

HCID 94475-Chlorosalicylic AcidHCID 6185364-(3,4-Dichlorophenyl)-1,3-thiazol-2-amine

Product 1

HCID 574592755-Chloro-N-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]-2-hydroxybenzamideYield 15.1%

Procedure

Using 5-chlorosalicylic acid and 2-amino-4-(3,4-dichlorophenyl)thiazole as the raw materials, the same operation as the Example 16 gave the title compound.

Sources & evidence

ORD record
ord-d9f263745aa1415e9cba394d18d8e43c
Source dataset
uspto-grants-2010_04
Patent number
US07700655B2

Reaction notes

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