Hexafluoroacetylacetone → 3,5-Bis(trifluoromethyl)-1-(3-nitrophenyl)pyrazole

HRID 644481Notes

Reaction equation

[CH2:1]([C:8]([C:10]([F:13])([F:12])[F:11])=O)[C:2]([C:4]([F:7])([F:6])[F:5])=O.Cl.[N+:15]([C:18]1[CH:19]=[C:20]([NH:24][NH2:25])[CH:21]=[CH:22][CH:23]=1)([O-:17])=[O:16]>>[F:11][C:10]([F:13])([F:12])[C:8]1[CH:1]=[C:2]([C:4]([F:7])([F:6])[F:5])[N:24]([C:20]2[CH:21]=[CH:22][CH:23]=[C:18]([N+:15]([O-:17])=[O:16])[CH:19]=2)[N:25]=1

Participants

Reactant 2

HCID 73706Hexafluoroacetylacetone

HCID 54642853-Nitrophenylhydrazinium(1+) chloride

Product 1

HCID 230699823,5-Bis(trifluoromethyl)-1-(3-nitrophenyl)pyrazoleYield 94%

Procedure

Using hexafluoroacetylacetone and 3-nitrophenylhydrazine hydrochloride as the raw materials, the same operation as the Example 538(1) gave the title compound.

Sources & evidence

ORD record: ord-9ac42a168d5149c4b044507459899af6
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07700655B2

Reaction notes

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