Sulfuric Acid → 2-Acetoxy-4-chlorobenzoic acid

HRID 644489Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([OH:11])[C:5](=[CH:9][CH:10]=1)[C:6]([OH:8])=[O:7].S(=O)(=O)(O)O.[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[C:17]([O:11][C:4]1[CH:3]=[C:2]([Cl:1])[CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7])(=[O:19])[CH3:18]

Participants

Reactant 3

HCID 1118Sulfuric Acid

HCID 7918Acetic Anhydride

HCID 787824-Chlorosalicylic acid

Product 1

HCID 152782562-Acetoxy-4-chlorobenzoic acidYield 88.1%

Procedure

Using 4-chlorosalicylic acid, concentrated sulfuric acid and acetic anhydride as the raw materials, the same operation as the Example 34(1) gave the title compound.

Sources & evidence

ORD record: ord-2971471c75da4d30835718251342dca5
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07700655B2

Reaction notes

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