4,4,4-Trifluoro-1-phenyl-1,3-butanedione → 1-(4-Nitrophenyl)-5-phenyl-3-(trifluoromethyl)pyrazole

HRID 644491Notes

Reaction equation

HRID 644491 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3](=O)[CH2:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=O.Cl.[N+:17]([C:20]1[CH:25]=[CH:24][C:23]([NH:26][NH2:27])=[CH:22][CH:21]=1)([O-:19])=[O:18]>>[N+:17]([C:20]1[CH:21]=[CH:22][C:23]([N:26]2[C:5]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)=[CH:4][C:3]([C:2]([F:15])([F:14])[F:1])=[N:27]2)=[CH:24][CH:25]=1)([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 675894,4,4-Trifluoro-1-phenyl-1,3-butanedioneHCID 54634014-Nitrophenylhydrazine hydrochloride

Product 1

HCID 154987441-(4-Nitrophenyl)-5-phenyl-3-(trifluoromethyl)pyrazoleYield 95.2%

Procedure

Using 4,4,4-trifluoro-1-phenyl-1,3-butanedione and 4-nitrophenylhydrazine hydrochloride as the raw materials, the same operation as the Example 538(1) gave the title compound.

Sources & evidence

ORD record
ord-d1206181a93f4698b82474ce30b369f7
Source dataset
uspto-grants-2010_04
Patent number
US07700655B2

Reaction notes

Loading…