5-Chlorosalicylic Acid → HCID 10092309, compound

HRID 644496Notes

Reaction equation

HRID 644496 reaction equation
[Cl:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[NH2:12][C:13]1[S:14][CH:15]=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[CH:19]=2)[N:17]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:12][C:13]1[S:14][CH:15]=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:27])([F:25])[F:26])[CH:19]=2)[N:17]=1)=[O:9]

Participants

3

Reactant 2

HCID 94475-Chlorosalicylic AcidHCID 7064574-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine

Product 1

HCID 10092309HCID 10092309, compoundYield 31%

Procedure

Using 5-chlorosalicylic acid and 2-amino-4-[3-(trifluoromethyl)phenyl]thiazole as the raw materials, the same operation as the Example 16 gave the title compound.

Sources & evidence

ORD record
ord-138274608cfc48df84105510ffbae63b
Source dataset
uspto-grants-2010_04
Patent number
US07700655B2

Reaction notes

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