2',3',4',5',6'-Pentafluoroacetophenone → 4-(2,3,4,5,6-Pentafluorophenyl)-2-thiazolamine

HRID 644497Notes

Reaction equation

HRID 644497 reaction equation
[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[C:5]([F:10])=[C:4]([F:11])[C:3]=1[C:12](=O)[CH3:13].[NH2:15][C:16]([NH2:18])=[S:17]>>[NH2:18][C:16]1[S:17][CH:13]=[C:12]([C:3]2[C:2]([F:1])=[C:7]([F:8])[C:6]([F:9])=[C:5]([F:10])[C:4]=2[F:11])[N:15]=1

Participants

3

Reactant 2

HCID 695462',3',4',5',6'-PentafluoroacetophenoneHCID 2723790Thiourea

Product 1

HCID 108493434-(2,3,4,5,6-Pentafluorophenyl)-2-thiazolamineYield 86.7%

Procedure

Using 2′,3′,4′,5′,6′-pentafluoroacetophenone and thiourea as the raw materials, the same operation as the Example 395(1) gave the title compound.

Sources & evidence

ORD record
ord-040d41b52dcd49deab12c7bf78c0128f
Source dataset
uspto-grants-2010_04
Patent number
US07700655B2

Reaction notes

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