5-Chlorosalicylic Acid → 5-Chloro-2-hydroxy-N-[4-(pentafluorophenyl)-1,3-thiazol-2-yl]benzamide

HRID 644498Notes

Reaction equation

HRID 644498 reaction equation
[Cl:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[NH2:12][C:13]1[S:14][CH:15]=[C:16]([C:18]2[C:23]([F:24])=[C:22]([F:25])[C:21]([F:26])=[C:20]([F:27])[C:19]=2[F:28])[N:17]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:12][C:13]1[S:14][CH:15]=[C:16]([C:18]2[C:19]([F:28])=[C:20]([F:27])[C:21]([F:26])=[C:22]([F:25])[C:23]=2[F:24])[N:17]=1)=[O:9]

Participants

3

Reactant 2

HCID 94475-Chlorosalicylic AcidHCID 108493434-(2,3,4,5,6-Pentafluorophenyl)-2-thiazolamine

Product 1

HCID 103874425-Chloro-2-hydroxy-N-[4-(pentafluorophenyl)-1,3-thiazol-2-yl]benzamideYield 23.8%

Procedure

Using 5-chlorosalicylic acid and 2-amino-4-(2,3,4,5,6-pentafluorophenyl)-thiazole as the raw materials, the same operation as the Example 16 gave the title compound.

Sources & evidence

ORD record
ord-0df4ba81dd594313a208c65ee6897014
Source dataset
uspto-grants-2010_04
Patent number
US07700655B2

Reaction notes

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