m-Formylbenzonitrile → 7-(N-(3-cyanobenzylidene)amino)-1-phenyl-5-trifluoromethylbenzimidazole

HRID 644505Notes

Reaction equation

HRID 644505 reaction equation
[NH2:1][C:2]1[C:7]2[N:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH:9]=[N:10][C:6]=2[CH:5]=[C:4]([C:17]([F:20])([F:19])[F:18])[CH:3]=1.[C:21]([C:23]1[CH:24]=[C:25]([CH:28]=[CH:29][CH:30]=1)[CH:26]=O)#[N:22]>>[C:21]([C:23]1[CH:24]=[C:25]([CH:28]=[CH:29][CH:30]=1)[CH:26]=[N:1][C:2]1[C:7]2[N:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH:9]=[N:10][C:6]=2[CH:5]=[C:4]([C:17]([F:20])([F:19])[F:18])[CH:3]=1)#[N:22]

Participants

3

Reactant 2

HCID 90670m-FormylbenzonitrileHCID 113003637-Amino-1-phenyl-5-trifluoromethylbenzimidazole

Product 1

HCID 112346827-(N-(3-cyanobenzylidene)amino)-1-phenyl-5-trifluoromethylbenzimidazole

Procedure

This was prepared analogously to the above product from 7-amino-1-phenyl-5-trifluoromethylbenzimidazole (1.0 g, 3.61 mmol) and 3-cyanobenzaldehyde (0.47 g, 3.61 mmol) yielding 0.90 g (64%) m/z, 391.1 (M+H)+.

Workup

  1. customyielding 0.90 g (64%) m/z, 391.1 (M+H)+

Sources & evidence

ORD record
ord-8ca22614259d43ada0aa843ec8fe24fd
Source dataset
uspto-grants-2010_04
Patent number
US07700638B2

Reaction notes

Loading…