1,3-Propanediol → HCID 11371743, compound

Participants

Reaction Steps

This was prepared analogously to the above product from 5-ethoxycarbonyl-7-iodo-1-phenylbenzimidazole (2.1 g, 5.36 mmol), 3-aminophenylboronic acid (1.1 g, 8.04 mmol), 1,3-propanediol (1.9 ml, 26.8 mmol), potassium carbonate (3.7 g, 26.8 mmol) and bis(triphenylphosphin)palladium dichloride (50 mg, 0.07 mmol) in a mixture of dimethoxyethane (10 ml) and water (5 ml). The title product was obtained as an off-white solid (1.30 g, 68%) m/z, 358.2 (M+H)+.

Provenance & Evidence