1,3-Propanediol → HCID 11303270, compound

Participants

Reaction Steps

This was prepared analogously to 7-(3-acetamidophenyl)-5-ethoxycarbonyl-1-phenylbenzimidazole from 5-ethoxycarbonyl-7-iodo-1-phenylbenzimidazole (2.7 g, 6.89 mmol), 3-(hydroxymethyl)phenylboronic acid (1.57 g, 10.3 mmol), 1,3-propanediol (2.5 ml, 34.4 mmol), potassium carbonate (4.75 g, 34.4 mmol) and bis(triphenylphosphin)palladium dichloride (100 mg, 0.14 mmol) in a mixture of dimethoxyethane (30 ml) and water (15 ml). The title product was obtained as an off-white solid (2.1 g, 82%) m/z, 373.2 (M+H)+.

Provenance & Evidence