HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 5-Cyano-7-(3-methoxyphenyl)-1-phenylbenzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (3-Methoxyphenyl)boronic acid | HCID 2734370 | — |
| Reactant | 7-(3-Acetamidophenyl)-5-cyano-1-phenylbenzimidazole | HCID 11245099 | — |
| Reactant | 5-Cyano-7-iodo-1-phenylbenzimidazole | HCID 67485627 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-Cyano-7-(3-methoxyphenyl)-1-phenylbenzimidazole | HCID 11198141 | 31.3% |
Reaction Steps
This was prepared from 5-cyano-7-iodo-1-phenylbenzimidazole (173 mg, 0.5 mmol), toluene (3.0 ml), tetrakis(triphenylphosphine)palladium(0) (58 mg, 0.05 mmol), 3-methoxyphenylboronic acid (76 mg, 0.5 mmol), ethanol (3.0 ml) and potassium carbonate (138 mg, 1.0 mmol) in a similar manner to 7-(3-acetamidophenyl)-5-cyano-1-phenylbenzimidazole. Purification by a similar procedure afforded the title compound (51 mg, 31%) m/z, 326.5 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700638B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-a36bb14a996b40bfb37a12a761d3d9f0 |
| Source note | uspto-grants-2010_04 |