HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 644535Generated: October 29, 2026
Morpholine → 7-(4-Morpholinyl)-1-phenyl-5-trifluoromethylbenzimidazole
https://huagongshe.com/reaction/644535
Participants
| Role | Name | HCID | Charge |
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| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 7-Fluoro-1-phenyl-5-trifluoromethylbenzimidazole | HCID 67485003 | — |
| Product | 7-(4-Morpholinyl)-1-phenyl-5-trifluoromethylbenzimidazole | HCID 11175433 | 13.1% |
Reaction Steps
To 7-fluoro-1-phenyl-5-trifluoromethylbenzimidazole (400 mg, 1.4 mmol) was added morpholine (1 ml, 1.1 mmol) and the mixture heated in a Personal Chemistry Smith Creator™ microwave for ten 30 minute periods at 245° C. The residue was chromatographed over silica gel to give the title compound as a solid (50 mg, 10%) m/z, 348.0 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07700638B2 |
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| Source dataset | uspto-grants-2010_04 |
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| ORD ID | ord-63b45bbb98d74b98b628dbb0b3028937 |
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| Source note | uspto-grants-2010_04 |
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