反应详情

To a suspension of 7-(3-acetylphenyl)-1-phenyl-5-trifluoromethylbenzimidazole (0.95 g, 2.5 mmol) in ethanol (10 ml) was added sodium borohydride (0.1 g, 2.6 mmol) and the resultant mixture was stirred at 60° C. for 20 min. The cooled reaction mixture was concentrated under reduced pressure and the concentrate was partitioned between ethyl acetate and water. The organic layer was dried over magnesium sulphate and concentrated to a small volume (1-2 ml) under reduced pressure. The title product precipitated upon addition of ligroin to the concentrate (0.65 g, 68%) m/z, 383.1 (M+H)+.

1. customThe cooled reaction mixture
2. concentrationwas concentrated under reduced pressure
3. customthe concentrate was partitioned between ethyl acetate and water
4. dry with materialThe organic layer was dried over magnesium sulphate
5. concentrationconcentrated to a small volume (1-2 ml) under reduced pressure
6. customThe title product precipitated upon addition of ligroin to the
7. concentrationconcentrate (0.65 g, 68%) m/z, 383.1 (M+H)+