反应详情

This was prepared from 3-(3-phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)acrylic acid methyl ester in a similar manner to 1-(4-methylpiperazin-1-yl)-3-(3-phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)prop-2-en-1-one. The oily residue was purified by flash chromatography over silica gel (eluted with dichloromethane/methanol 2-5% gradient) to afford the title compound as a white solid (29 mg, 5%), m/z 403.4 (M+H)+.

1. customThe oily residue was purified by flash chromatography over silica gel (eluted with dichloromethane/methanol 2-5% gradient)