1-(4-Methylpiperazin-1-yl)-3-(3-phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)prop-2-en-1-one → HCID 72831106, compound

HRID 644546Notes

Reaction equation

HRID 644546 reaction equation
C[O:2][C:3](=O)[CH:4]=[CH:5][C:6]1[C:14]2[N:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:12]=[N:11][C:10]=2[CH:9]=[C:8]([C:21]([F:24])([F:23])[F:22])[CH:7]=1.CN1CCN(C(=O)C=CC2C3N(C4C=CC=CC=4)[CH:42]=[N:41][C:40]=3[CH:39]=[C:38]([C:51]([F:54])([F:53])[F:52])[CH:37]=2)CC1>>[C:15]1([N:13]2[C:14]3[C:6]([CH:5]=[CH:4][C:3]([N:41]4[CH2:42][CH2:37][CH:38]([C:51]([F:54])([F:53])[F:52])[CH2:39][CH2:40]4)=[O:2])=[CH:7][C:8]([C:21]([F:22])([F:24])[F:23])=[CH:9][C:10]=3[N:11]=[CH:12]2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 674849301-(4-Methylpiperazin-1-yl)-3-(3-phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)prop-2-en-1-oneHCID 674849573-(3-Phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)acrylic acid methyl ester

Product 1

HCID 72831106HCID 72831106, compound

Procedure

This was prepared from 3-(3-phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)acrylic acid methyl ester in a similar manner to 1-(4-methylpiperazin-1-yl)-3-(3-phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)prop-2-en-1-one. The oily residue was purified by preparative LCMS to afford, after removal of the solvent, the title compound as a white solid (40 mg, 12%), m/z 468.2 (M+H)+.

Workup

  1. customThe oily residue was purified by preparative LCMS
  2. customto afford
  3. customafter removal of the solvent

Sources & evidence

ORD record
ord-592a60e8109f4ef4b508f64d85c0680b
Source dataset
uspto-grants-2010_04
Patent number
US07700638B2

Reaction notes

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