反应详情

Alumina supported formate was prepared according to the procedure of Danks and Desai (T. N. Danks and B. Desai, Green Chemistry, 2002, 4, 179-180). A Smith Process Vial™ was loaded with alumina supported formate (0.5 g), Wilkinson's catalyst (0.5 mg), N,N-diethyl-3-(3-phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)acrylamide (0.064 mmol, 25 mg) and dimethylsulphoxide (0.5 ml) and was irradiated for 600 s at 180° C. using a Personal Chemistry Smith Creator™ microwave. The mixture was filtered to remove the solid support and the filtrate was purified by LCMS to give, after evaporation, the title compound as a solid (7.8 mg, 31%), m/z 390.0 (M+H)+.

1. customwas prepared
2. customwas irradiated for 600 s at 180° C.
3. filtrationThe mixture was filtered
4. customto remove the solid support
5. customthe filtrate was purified by LCMS
6. customto give
7. customafter evaporation