1-(4-Methylpiperazin-1-yl)-3-(3-phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)prop-2-en-1-one → HCID 68679761, compound

HRID 644550Notes

Reaction equation

HRID 644550 reaction equation
C[O:2][C:3](=O)[CH:4]=[CH:5][C:6]1[C:14]2[N:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:12]=[N:11][C:10]=2[CH:9]=[C:8]([C:21]([F:24])([F:23])[F:22])[CH:7]=1.CN1CCN(C(=O)C=C[C:36]2[C:44]3[N:43]([C:45]4C=CC=C[CH:46]=4)C=N[C:40]=3C=C(C(F)(F)F)C=2)CC1>>[CH2:45]([N:43]([CH:44]([CH3:36])[CH3:40])[C:3](=[O:2])[CH:4]=[CH:5][C:6]1[C:14]2[N:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:12]=[N:11][C:10]=2[CH:9]=[C:8]([C:21]([F:23])([F:22])[F:24])[CH:7]=1)[CH3:46]

Participants

3

Reactant 2

HCID 674849301-(4-Methylpiperazin-1-yl)-3-(3-phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)prop-2-en-1-oneHCID 674849573-(3-Phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)acrylic acid methyl ester

Product 1

HCID 68679761HCID 68679761, compoundYield 6%

Procedure

This was prepared from 3-(3-phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)acrylic acid methyl ester in a similar manner to 1-(4-methylpiperazin-1-yl)-3-(3-phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)prop-2-en-1-one. The oily residue was purified by preparative LCMS to afford the title compound as a white solid (7.2 mg, 6%), m/z 402.0 (M+H)+.

Workup

  1. customThe oily residue was purified by preparative LCMS

Sources & evidence

ORD record
ord-08d0a68438bc48a7a9b278fe0d36c0c0
Source dataset
uspto-grants-2010_04
Patent number
US07700638B2

Reaction notes

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