1-(4-Methylpiperazin-1-yl)-3-(3-phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)prop-2-en-1-one → HCID 85417601, compound

HRID 644551Notes

Reaction equation

HRID 644551 reaction equation
COC(=O)C=CC1C2N(C3C=CC=CC=3)C=NC=2C=C(C(F)(F)F)C=1.CN1[CH2:32][CH2:31][N:30]([C:33](=[O:55])[CH:34]=[CH:35][C:36]2[C:44]3[N:43]([C:45]4[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=4)[CH:42]=[N:41][C:40]=3[CH:39]=[C:38]([C:51]([F:54])([F:53])[F:52])[CH:37]=2)[CH2:29][CH2:28]1>>[C:45]1([N:43]2[C:44]3[C:36]([CH:35]=[CH:34][C:33]([N:30]4[CH2:31][CH2:32][CH2:28][CH2:29]4)=[O:55])=[CH:37][C:38]([C:51]([F:54])([F:52])[F:53])=[CH:39][C:40]=3[N:41]=[CH:42]2)[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1

Participants

3

Reactant 2

HCID 674849301-(4-Methylpiperazin-1-yl)-3-(3-phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)prop-2-en-1-oneHCID 674849573-(3-Phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)acrylic acid methyl ester

Product 1

HCID 85417601HCID 85417601, compoundYield 7%

Procedure

This was prepared from 3-(3-phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)acrylic acid methyl ester in a similar manner to 1-(4-methylpiperazin-1-yl)-3-(3-phenyl-6-trifluoromethyl-3H-benzimidazol-4-yl)prop-2-en-1-one. The oily residue was purified by preparative LCMS to afford the title compound as a white solid (7.3 mg, 7%), m/z 386.0 (M+H)+.

Workup

  1. customThe oily residue was purified by preparative LCMS

Sources & evidence

ORD record
ord-8bab69bf79574780bd50adbcdc81c8c8
Source dataset
uspto-grants-2010_04
Patent number
US07700638B2

Reaction notes

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