4-Chloro-3,5-dinitrobenzotrifluoride → 7-Amino-1-phenyl-5-trifluoromethylbenzimidazole

HRID 644557Notes

Reaction equation

HRID 644557 reaction equation
N[C:2]1[C:7]2[N:8](C3C=CC=CC=3)[CH:9]=N[C:6]=2[CH:5]=[C:4](C#N)[CH:3]=1.Cl[C:20]1[C:25]([N+:26]([O-])=O)=[CH:24][C:23]([C:29]([F:32])([F:31])[F:30])=[CH:22][C:21]=1[N+:33]([O-])=O>>[NH2:26][C:25]1[C:20]2[N:8]([C:7]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH:9]=[N:33][C:21]=2[CH:22]=[C:23]([C:29]([F:32])([F:31])[F:30])[CH:24]=1

Participants

3

Reactant 2

HCID 98094-Chloro-3,5-dinitrobenzotrifluorideHCID 674850457-Amino-5-cyano-1-phenylbenzimidazole

Product 1

HCID 113003637-Amino-1-phenyl-5-trifluoromethylbenzimidazole

Procedure

This was prepared in analogy with 7-amino-5-cyano-1-phenylbenzimidazole using 4-chloro-3,5-dinitrobenzotrifluoride as the starting material (11 g, 75%)

Sources & evidence

ORD record
ord-e583b98fc9734fbeb28c940e61e465c4
Source dataset
uspto-grants-2010_04
Patent number
US07700638B2

Reaction notes

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