Water → HCID 68579606, compound

HRID 644564Notes

Reaction equation

HRID 644564 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]([C:9]1([C:14]2[CH:15]=[C:16]([CH2:20][CH2:21][C:22]3[CH:23]=[C:24]([C:32](OC)=[O:33])[C:25](=[CH:30][CH:31]=3)[C:26](OC)=[O:27])[CH:17]=[CH:18][CH:19]=2)[O:13][CH2:12][CH2:11][O:10]1)[CH3:8].O.C(=O)([O-])[O-].[Na+].[Na+]>C(OCC)C>[CH2:7]([C:9]1([C:14]2[CH:15]=[C:16]([CH2:20][CH2:21][C:22]3[CH:31]=[CH:30][C:25]([CH2:26][OH:27])=[C:24]([CH2:32][OH:33])[CH:23]=3)[CH:17]=[CH:18][CH:19]=2)[O:10][CH2:11][CH2:12][O:13]1)[CH3:8]

Participants

6

Reactant 4

HCID 962Water2×HCID 10340Sodium CarbonateHCID 21226445Aluminium lithium hydrideHCID 68579556HCID 68579556, compound

Product 1

HCID 68579606HCID 68579606, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

2.9 g (75 mmol) of lithium aluminum hydride are suspended in 20 ml of ethyl ether. A solution of 7.5 g (19 mmol) of dimethyl 4-{2-[3-(2-ethyl[1,3]dioxolan-2-yl)phenyl]ethyl}phthalate in 100 ml of ethyl ether is added drop by drop. After stirring at ambient temperature for 20 minutes, the reaction medium is treated by addition of 15 ml of water, 1.5 ml of 15% sodium carbonate and 4.5 ml of water, then filtered and concentrated under reduced pressure. A colorless oil is obtained (m=6.4 g; Y=99%).

Workup

  1. filtrationfiltered
  2. concentrationconcentrated under reduced pressure
  3. customA colorless oil is obtained (m=6.4 g; Y=99%)

Sources & evidence

ORD record
ord-616d5ef46b0f4109935457fd2406f67c
Source dataset
uspto-grants-2010_04
Patent number
US07700657B2

Reaction notes

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