HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxybenzaldehyde → 3-(t-Butyldimethylsilyloxy)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxybenzaldehyde | HCID 101 | — |
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Product | 3-(t-Butyldimethylsilyloxy)benzaldehyde | HCID 11207111 | — |
Reaction Steps
In a manner analogous to example 1 g, by reaction of 42.7 g (0.275 mol) of tert-butyldimethylchlorosilane with 30.5 g (0.2 mol) of 3-hydroxybenzaldehyde and (20.4 g, 0.3 mol) of imidazole. After purification on a silica column (dichloromethane 20-heptane 80), a yellow oil is obtained (m=55.9 g; Y=95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700657B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-e2eaf4bc612e4ac2ab13360e0fba7500 |
| Source note | uspto-grants-2010_04 |