HRID644568

反应详情

EQUATION

反应方程式

HRID 644568 的结构方程式

AUXILIARIES

试剂、催化剂与溶剂

1

CONDITIONS

反应条件

温度
0 °C

PROCEDURE

实验过程

50 g (0.21 mol) of 3-(tert-butyldimethyl-silanyloxy)benzaldehyde are dissolved in 500 ml of ethyl ether and the mixture is cooled to 0° C. 80 ml (0.24 mol) of a 3.0 M solution of ethylmagnesium bromide are added slowly, and the mixture is stirred for 5 hours. After the usual treatment, the residue obtained is purified by chromatography on a silica column (eluent ethyl acetate 20/hexane 80). A colorless oil is obtained (m=45.8 g; Y=82%).

WORKUP

后处理

  1. customAfter the usual treatment, the residue obtained
  2. customis purified by chromatography on a silica column (eluent ethyl acetate 20/hexane 80)
  3. customA colorless oil is obtained (m=45.8 g; Y=82%)