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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 644696Generated: October 29, 2026

4-Nitrobenzaldehyde → 1,1-Dimethylethyl (2R)-2-methyl-4-[(4-nitrophenyl)methyl]-1-piperazinecarboxylate

https://huagongshe.com/reaction/644696

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-NitrobenzaldehydeHCID 541—
Reactant(R)-tert-butyl 2-methylpiperazine-1-carboxylate hydrochlorideHCID 45072184—
Reactant1,1-Dimethylethyl (2S)-2-methyl-4-[(4-nitrophenyl)methyl]-1-piperazinecarboxylateHCID 59262204—
Product1,1-Dimethylethyl (2R)-2-methyl-4-[(4-nitrophenyl)methyl]-1-piperazinecarboxylateHCID 59262157—

Reaction Steps

The title compound was prepared from 4-nitrobenzaldehyde and 1,1-dimethylethyl (2R)-2-methyl-1-piperazinecarboxylate hydrochloride using a method similar to that described for D1 in Description 1. MS (ES+): 280.2, 236.3, no molecular ion (MH+) observed

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07700599B2
Source datasetuspto-grants-2010_04
ORD IDord-fdec3d1203b742de8dff1db72887c06c
Source noteuspto-grants-2010_04