HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrobenzaldehyde → 1-Boc-4-(4-Nitrobenzyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrobenzaldehyde | HCID 541 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 1,1-Dimethylethyl (2S)-2-methyl-4-[(4-nitrophenyl)methyl]-1-piperazinecarboxylate | HCID 59262204 | — |
| Product | 1-Boc-4-(4-Nitrobenzyl)piperazine | HCID 23506946 | — |
Reaction Steps
The title compound was prepared from 4-nitrobenzaldehyde and 1,1-dimethylethyl 1-piperazinecarboxylate using a method similar to that described for D1 in Description 1A although the product was purified by column chromatography followed by passing through an SCX column eluting with MeOH then 2M NH3 in MeOH. MS (ES+): 266.1, 222.2, no molecular ion (MH+) observed.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700599B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-55c78fd3b90946c8a3bee5f16d89b4b8 |
| Source note | uspto-grants-2010_04 |