HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Cyanophenol → 1,1-Dimethylethyl (2S)-4-({4-[({5-[(3-cyanophenyl)oxy]-2-pyridinyl}carbonyl)(methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Cyanophenol | HCID 13394 | — |
| Reactant | 1,1-Dimethylethyl (2S)-4-({4-[[(5-bromo-2-pyridinyl)carbonyl](methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate | HCID 59262238 | — |
| Product | 1,1-Dimethylethyl (2S)-4-({4-[({5-[(3-cyanophenyl)oxy]-2-pyridinyl}carbonyl)(methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate | HCID 59262195 | — |
Reaction Steps
The title compound was prepared from 1,1-dimethylethyl (2S)-4-({4-[[(5-bromo-2-pyridinyl)carbonyl](methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate (D72) and 3-cyanophenol using a method similar to that described for D73 in Description 73 although the reaction was worked up after the first night of heating. MS (ES): MH+ 542.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700599B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-308ac1d9af7649ac9aea594c7af6da37 |
| Source note | uspto-grants-2010_04 |