反应详情

温度

50 °C

To 1,1-dimethylethyl (2S)-4-[(6-amino-4-methyl-3-pyridinyl)methyl]-2-methyl-1-piperazinecarboxylate (D100) (0.067 g, 0.21 mmol) in dry MeOH (4 mL) under an argon atmosphere was added paraformaldehyde (0.019 g, 0.63 mmol) and sodium methoxide (0.057 g, 1.00 mmol). The mixture was stirred at 50° C. overnight then sodium borohydride (0.024 g, 0.63 mmol) was added and the reaction stirred at 50° C. for 24 h. The reaction mixture was concentrated in vacuo. The residue was partitioned between DCM and saturated aqueous NaHCO3 and stirred for 0.5 h. The aqueous phase was extracted with DCM (3×5 mL) and the combined organics were dried and concentrated to give a crude colourless oil. Column chromatography eluting with 0-10% MeOH/DCM gave the crude title compound as a colourless oil (0.037 g) which was used in the next step without further purification. MS (ES): MH+ 335.3.

1. stirringthe reaction stirred at 50° C. for 24 h
2. concentrationThe reaction mixture was concentrated in vacuo
3. customThe residue was partitioned between DCM and saturated aqueous NaHCO3
4. stirringstirred for 0.5 h
5. extractionThe aqueous phase was extracted with DCM (3×5 mL)
6. customthe combined organics were dried
7. concentrationconcentrated
8. customto give a crude colourless oil
9. washColumn chromatography eluting with 0-10% MeOH/DCM