HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluorophenol → 1,1-Dimethylethyl (2S)-4-({4-[({6-[(3-fluorophenyl)oxy]-2-pyridinyl}carbonyl) (methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluorophenol | HCID 9743 | — |
| Reactant | 1,1-Dimethylethyl (2S)-4-({4-[[(6-chloro-2-pyridinyl)carbonyl](methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate | HCID 59262188 | — |
| Product | 1,1-Dimethylethyl (2S)-4-({4-[({6-[(3-fluorophenyl)oxy]-2-pyridinyl}carbonyl) (methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate | HCID 59262224 | — |
Reaction Steps
The title compound was prepared from 1,1-dimethylethyl (2S)-4-({4-[[(6-chloro-2-pyridinyl)carbonyl](methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate (D107) and 3-fluorophenol using a procedure similar to that described for D125 in Description 125 although the reaction time was 3.3 h. MS (ES): MH+ 535.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700599B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-57486eb377d24d048d9df3e3a56c67ea |
| Source note | uspto-grants-2010_04 |