Propanal → HCID 86605582, compound

Participants

Reaction Steps

Benzotriazole (2.14 g, 18 mmol) and dry toluene (24 mL) were charged to a flask under an argon atmosphere. A solution of 5-amino-1,3-dimethylpyrazole (2 g, 18 mmol) in toluene (10 mL) was added to the benzotriazole solution over approximately 0.5 min, followed by the drop-wise addition of propionaldehyde (1.14 g, 19.8 mmol). After this reaction mixture was stirred for 24 hours, n-heptane (30 mL) was added and slurry was stirred for an additional 1 hour, after which time the n-heptane was decanted off, and the pasty residue was dried under vacuum to afford the title compound (4.04 g, 83%).

Provenance & Evidence