Water → HCID 58662432, compound

Participants

Reaction Steps

To a stirred solution of [(3,5-Bis-trifluoromethyl-benzylidene)-amino]-6-ethyl-1,3-dimethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-b]pyridine-7-carboxylic acid ethyl ester (0.19 g, 0.04 mmol) obtained in step (v), in 10 mL of methanol was added sodium cyanoborohydride (0.078 g, 0.12 mmol). This reaction mixture was stirring for around 3 hours at room temperature, after which time the methanol was evaporated from the solution to afford a crude residue. Water was added to this residue, and the product was extracted with ethyl acetate (3×10 mL). The organic solvent was dried over sodium sulfate, filtered, and the solvent was evaporated from the filtrate under vacuum to provide the desired amine compound (0.019 g, 95%).

Provenance & Evidence