Diphenyl Ether → Ethyl 4-Hydroxy-6,8-dimethyl-1,7-naphthyridine-3-carboxylate

Participants

Reaction Conditions

Reaction Steps

2-[(2,6-Dimethyl-pyridin-3-ylamino)-methylene]-malonic acid diethyl ester, prepared in step (i) and diphenyl ether (DPE) were placed in a round bottom flask and this mixture was heated to 260° C. for 1 h. The reaction was then cooled to RT and the content was purified by column chromatography over 100-200 mesh silica gel, eluted with 8% methanol in chloroform, to give the product as a brown solid (36%).

Provenance & Evidence