Ethanol → HCID 17862430, compound

HRID 644844Notes

Reaction equation

HRID 644844 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]([N+:15]([O-:17])=[O:16])=[C:6]([O:8][C:9]2[CH:13]=[C:12]([CH3:14])[NH:11][N:10]=2)[CH:7]=1.C(=O)([O-])O.[K+].[CH2:23]([OH:25])[CH3:24]>>[CH2:23]([O:25][C:2]1[CH:3]=[CH:4][C:5]([N+:15]([O-:17])=[O:16])=[C:6]([O:8][C:9]2[CH:13]=[C:12]([CH3:14])[NH:11][N:10]=2)[CH:7]=1)[CH3:24]

Participants

4

Reactant 3

HCID 702EthanolHCID 516893Potassium BicarbonateHCID 17862422HCID 17862422, compound

Product 1

HCID 17862430HCID 17862430, compoundYield 59.8%

Procedure

Reaction of 3-(5-fluoro-2-nitrophenyloxy)-5-methylpyrazole with ethanol was carried out in the presence of potassium hydrogencarbonate in the same manner as in Example 40, to give a yellow viscous substance of 3-(5-ethoxy-2-nitrophenyloxy)-5-methylpyrazole (yield: 59.8%). 1H-NMR (CDCl3, TMS, ppm): δ 1.39 (t, J=7.0 Hz, 3H), 2.28 (s, 3H), 4.04 (q, J=7.0 Hz, 2H), 5.72 (s, 1H), 6.68 (dd, J=2.6 and 9.1 Hz, 1H), 6.73 (d, J=2.6 Hz, 1H), 8.04 (d, J=9.1 Hz, 1H), 9.62 (br s, 1H).

Sources & evidence

ORD record
ord-9f0c6a53ba7e4beeb0ce552eeaff1c90
Source dataset
uspto-grants-2010_04
Patent number
US07700786B2

Reaction notes

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