Methyl Isocyanate → HCID 17862354, compound

HRID 644892Notes

Reaction equation

[Cl:1][C:2]1[C:3]([O:12][C:13]2[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[NH:15][N:14]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[CH3:22][N:23]=[C:24]=[O:25]>>[CH3:22][NH:23][C:24]([N:15]1[C:16]([C:18]([F:21])([F:19])[F:20])=[CH:17][C:13]([O:12][C:3]2[C:2]([Cl:1])=[CH:7][C:6]([C:8]([F:10])([F:9])[F:11])=[CH:5][N:4]=2)=[N:14]1)=[O:25]

Participants

Reactant 2

HCID 12228Methyl Isocyanate

HCID 17862453HCID 17862453, compound

Product 1

HCID 17862354HCID 17862354, compoundYield 20.1%

Procedure

Reaction of 3-(3-chloro-5-trifluoromethylpyridin-2-yloxy)-5-trifluoromethylpyrazole with methyl isocyanate was carried out in the same manner as in Example 173, to give a white solid of N-methyl-3-(3-chloro-5-trifluoromethylpyridin-2-yloxy)-5-trifluoromethylpyrazole-1-carboxamide (0.39 g, yield: 20.1%). mp: 61-63° C.; 1H-NMR (CDCl3, TMS, ppm): δ 3.52 (s, 3H), 5.66 (s, 1H), 8.00 (d, J=11.8 Hz, 1H), 8.61 (d, J=1.8 Hz, 1H), 10.10-10.40 (m, 1H).

Sources & evidence

ORD record: ord-66eb6fbcfc734f17893f1ed9ce231445
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07700786B2

Reaction notes

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