2-(3-Fluorophenyl)ethanamine → HCID 59263921, compound

Participants

Reaction Conditions

Reaction Steps

2-(3-Fluorophenyl)ethanamine (0.573 mL) was added to benzyl {2-[acryloyl(cycloheptyl)amino]ethyl}[2-(4-hydroxy-2-oxo-2,3-dihydro-1,3-benzothiazol-7-yl)ethyl]carbamate, prepared as in Example 23 step ii), (0.786 g) in ethanol (15 mL). The resulting solution was stirred at 50° C. for 32 h. The volatiles were removed in vacuo and the crude material was purified by flash silica chromatography, elution gradient 0.5:0.5:19 to 1:7:13 7M NH3 in methanol:ethanol:ethyl acetate. Pure fractions were evaporated to dryness to afford the sub-title product (0.759 g) as a pale yellow foam.

Provenance & Evidence